The Chiron has standard head airbag curtains which act as a forgiving barrier between the driver and outboard passenger's upper bodies and the window and pillars. Combined with high-strength steel door beams and lower side airbags this system increases head protection in broadside collisions. The Senna doesn't offer side airbag protection for the head.
The Chiron has all-wheel drive to maximize traction under poor conditions, especially in ice and snow. The Senna doesn’t offer all-wheel drive.
Both the Chiron and the Senna have standard driver and passenger frontal airbags, front side-impact airbags, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding and daytime running lights.
The Bugatti Chiron weighs 1136 to 1336 pounds more than the McLaren Senna. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts. Crosswinds also affect lighter cars more.

