The Chiron has standard head airbag curtains which act as a forgiving barrier between the driver and outboard passenger's upper bodies and the window and pillars. Combined with high-strength steel door beams and lower side airbags this system increases head protection in broadside collisions. The 296 GTB doesn't offer side airbag protection for the head.
The Chiron has all-wheel drive to maximize traction under poor conditions, especially in ice and snow. The 296 GTB doesn’t offer all-wheel drive.
The Chiron has a standard 360 degree parking monitor to allow the driver to see objects all around the vehicle on a screen. The 296 GTB only offers a rear monitor and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the front or sides.
Both the Chiron and the 296 GTB have standard driver and passenger frontal airbags, front side-impact airbags, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, daytime running lights and rearview cameras.
The Bugatti Chiron weighs 957 to 1157 pounds more than the Ferrari 296 GTB. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.

