The GLS’ pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The GX doesn’t offer pre-crash pretensioners.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLS has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The GX doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
For better protection of the passenger compartment, the GLS uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The GX uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the GLS and the GX have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.

