The GLS has a standard Post Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The QX60 doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the GLS. But it costs extra on the QX60.
When descending a steep, off-road slope, the GLS’ standard Downhill Speed Regulation allows you to creep down safely. The QX60 doesn’t offer Downhill Speed Regulation.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLS has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The QX60 doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the GLS and QX60 have rear cross-traffic warning, but the GLS has Active Brake Assist (automatically applies the brakes) to better prevent a collision when backing near traffic. The QX60’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the GLS and the QX60 have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras and rear cross-path warning.
The Mercedes GLS weighs 781 to 1681 pounds more than the Infiniti QX60. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

