The CLE has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The Z4 doesn’t offer front seat center airbags.
The CLE has all-wheel drive to maximize traction under poor conditions, especially in ice and snow. The Z4 doesn’t offer all-wheel drive.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The CLE has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Z4 doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
The CLE offers an optional Surround View System to allow the driver to see objects all around the vehicle on a screen. The Z4 only offers a rear monitor and front and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the sides.
The CLE has a standard blind spot warning system that uses sensors to alert the driver to objects in the vehicle’s blind spots where the side view mirrors don’t reveal them. A system to reveal vehicles in the Z4’s blind spot costs extra.
To help make backing out of a parking space safer, the CLE has standard Rear Cross-Traffic Alert and Active Brake Assist automatically engages the brakes to help avoid a collision. BMW charges extra for Cross Traffic Warning on the Z4 and the Z4’s Cross Traffic Warning does not include automatic braking.
Both the CLE and the Z4 have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, rearview cameras, driver alert monitors and available lane departure warning systems.
The Mercedes CLE weighs 514 to 1172 pounds more than the BMW Z4. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.

