Both the Vistiq and Grand Highlander have child safety locks to prevent children from opening the rear doors. The Vistiq has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Grand Highlander’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Cadillac Vistiq has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags help prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The Grand Highlander doesn’t offer a front passenger side knee airbag.
The Vistiq has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The Grand Highlander doesn’t offer front seat center airbags.
To provide maximum traction and stability on all roads, Full-Time Four-Wheel Drive is standard on the Vistiq. But it costs extra on the Grand Highlander.
A passive infrared night vision system standard on the Vistiq Premium Luxury/Platinum helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The Grand Highlander doesn’t offer a night vision system.
To help make backing out of a parking space safer, the Vistiq has standard Rear Cross Traffic Alert with Rear Cross Traffic Braking, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Only the Grand Highlander Limited/Platinum/Nightshade offers Parking Support Brake.
Both the Vistiq and the Grand Highlander have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
The Cadillac Vistiq weighs 1421 to 2036 pounds more than the Toyota Grand Highlander. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

