Compare the2026 Lexus LSVS 2025 Mercedes E-Class Sedan

The Lexus LS has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags help prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The E-Class Sedan doesn’t offer a front passenger side knee airbag.

To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the LS. But it costs extra on the E-Class Sedan.

The LS’ standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the E-Class Sedan.

The Lexus LS’ rear backup camera has a standard washer for maintaining a clear view under various conditions. In contrast, the Mercedes E-Class Sedan does not offer a rear camera washer, meaning its effectiveness relies on manual cleaning by the user when necessary.

Both the LS and the E-Class Sedan have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, around view monitors, rear cross-path warning and driver alert monitors.

The Lexus LS weighs 529 to 771 pounds more than the Mercedes E-Class Sedan. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.

Lexus’ powertrain warranty covers the LS 2 years and 20,000 miles longer than Mercedes covers the E-Class Sedan. Any repair needed on the engine, transmission, axles, joints or driveshafts is fully covered for 6 years or 70,000 miles. Coverage on the E-Class Sedan ends after only 4 years or 50,000 miles.

The LS’ corrosion warranty is 1 year longer than the E-Class Sedan’s (6 vs. 5 years).

A reliable vehicle saves its owner time, money and trouble. Nobody wants to be stranded or have to be without a vehicle while it’s being repaired. Consumer Reports rates the LS’ reliability 19 points higher than the E-Class Sedan.

J.D. Power and Associates’ 2025 Initial Quality Study of new car owners surveyed provide the statistics that show that Lexus vehicles are better in initial quality than Mercedes vehicles. J.D. Power ranks Lexus first in initial quality, above the industry average. With 44 more problems per 100 vehicles, Mercedes is ranked 21st, below the industry average.

J.D. Power and Associates’ 2025 survey of the owners of three-year-old vehicles provides the statistics that show that Lexus vehicles are more reliable than Mercedes vehicles. J.D. Power ranks Lexus first in reliability, above the industry average. With 103 more problems per 100 vehicles, Mercedes is ranked 28th.

The LS’ 3.4 turbo V6 produces 161 more horsepower (416 vs. 255) and 147 lbs.-ft. more torque (442 vs. 295) than the E 350 Sedan’s standard 2.0 turbo 4-cylinder hybrid. The LS’ 3.4 turbo V6 produces 41 more horsepower (416 vs. 375) and 73 lbs.-ft. more torque (442 vs. 369) than the E 450 Sedan’s standard 3.0 turbo 6-cylinder hybrid.

As tested in Consumer Reports the Lexus LS is faster than the E 350 Sedan 2.0 turbo 4-cylinder hybrid:

The LS has 4.3 gallons more fuel capacity than the E-Class Sedan (21.7 vs. 17.4 gallons), for longer range between fill-ups.

A 10-speed automatic is standard on the Lexus LS, for better acceleration and lower engine speed on the highway. Only a nine-speed automatic is available for the E-Class Sedan.

For better stopping power the LS’ standard brake rotors are larger than those on the E-Class Sedan:

For better traction, the LS has larger tires than the E-Class Sedan (245/45R20 vs. 225/55R18).

The LS’ tires provide better handling because they have a lower 45 series profile (height to width ratio) that provides a stiffer sidewall than the E-Class Sedan’s standard 55 series tires.

For better ride, handling and brake cooling the LS has standard 20-inch wheels. Smaller 18-inch wheels are standard on the E-Class Sedan.

Changing a flat tire near traffic can be dangerous and inconvenient. The run-flat tires standard on the LS can be driven up to 50 miles without any air pressure, allowing you to drive to a service station for a repair. Run-flat tires aren’t available on some tire packages on the E-Class Sedan.

For a smoother ride and more stable handling, the LS’ wheelbase is 6.4 inches longer than on the E-Class Sedan (123 inches vs. 116.6 inches).

The LS uses computer-generated active noise cancellation to help remove annoying noise and vibration from the passenger compartment, especially at low frequencies. The E-Class Sedan doesn’t offer active noise cancellation.

The LS has 1 inch more front shoulder room and 2.7 inches more rear legroom than the E-Class Sedan.

The LS has a much larger trunk than the E-Class Sedan (17 vs. 12.7 cubic feet).

J.D. Power and Associates surveys of service recipients show that Lexus service is better than Mercedes. J.D. Power ranks Lexus second in service department satisfaction. With a 26% lower rating, Mercedes is ranked 14th.

In poor weather, headlights can lose their effectiveness as grime builds up on their lenses. This can reduce visibility without the driver realizing. The LS has standard headlight washers to keep headlight output high. The E-Class Sedan doesn’t offer headlight washers.

The LS has a standard heated steering wheel to take the chill out of steering on extremely cold winter days before the car heater warms up. A heated steering wheel costs extra on the E-Class Sedan.

According to iSeeCars.com the 2025 Lexus LS retains 51.31% of its original value after 5 years, significantly more than the 43.07% resale value of the 2025 Mercedes E-Class Sedan after five years, which can save the Lexus’ owner.