For enhanced safety, the front and second-row seat shoulder belts of the Mercedes GLE have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Porsche Cayenne doesn’t offer pretensioners for its rear seat belts.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the GLE are reminded to check the back seat if they opened the rear door before starting out. The Cayenne doesn’t offer a back seat reminder.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLE has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Cayenne doesn’t offer a system that can receive automated systems from other vehicles.
Both the GLE and the Cayenne have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, around view monitors, rear cross-path warning, driver alert monitors and available lane departure warning systems.
The Mercedes GLE (with optional crash prevention) has achieved the Insurance Institute for Highway Safety’s (IIHS) highest rating of “Top Safety Pick Plus” for the 2025 model year. This distinction is based on its exceptional performance in IIHS’ rigorous battery of safety tests. Specifically, it earned a “Good” rating in the latest, more stringent moderate overlap front crash test, a “Good” result in the updated side impact test, and an “Acceptable” score in the revised pedestrian crash prevention test. The Cayenne has not yet been evaluated by the IIHS for 2025.