The Cayenne’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The 4Runner doesn’t offer pre-crash pretensioners.
Both the Cayenne and 4Runner have child safety locks to prevent children from opening the rear doors. The Cayenne has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The 4Runner’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the Cayenne. But it costs extra on the 4Runner.
A passive infrared night vision system optional on the Cayenne helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The 4Runner doesn’t offer a night vision system.
To help make backing out of a parking space safer, the Cayenne has standard Rear Cross Traffic Alert with automatic braking, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Only the 4Runner Limited/Platinum/Trailhunter/TRD Pro offers Parking Support Brake.
For better protection of the passenger compartment, the Cayenne uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The 4Runner uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Cayenne and the 4Runner have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.

