Both the Cullinan and Escalade-V have child safety locks to prevent children from opening the rear doors. The Cullinan has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Escalade-V’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Cullinan has standard PostCrash, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Escalade-V doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
For better protection of the passenger compartment, the Cullinan uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The Escalade-V uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Cullinan and the Escalade-V have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, around view monitors, rear cross-path warning, driver alert monitors and available night vision systems.