Compare the2025 Audi S4VS 2025 Mercedes AMG C-Class Sedan

Both the S4 and AMG C-Class Sedan have child safety locks to prevent children from opening the rear doors. The S4 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The AMG C-Class Sedan’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.

The Audi S4 has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The AMG C-Class Sedan doesn’t offer a front passenger side knee airbag.

The S4’s standard pretensioning seatbelts also sense rear collisions and remove slack from the seatbelts to help protect the occupants from whiplash and other injuries. The AMG C-Class Sedan doesn’t offer a whiplash protection system.

The S4’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the AMG C-Class Sedan.

Both the S4 and the AMG C-Class Sedan have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, rearview cameras, available blind spot warning systems, around view monitors and rear cross-path warning.

The S4’s corrosion warranty is 7 years longer than the AMG C-Class Sedan’s (12 vs. 5 years).

A reliable vehicle saves its owner time, money and trouble. Nobody wants to be stranded or have to be without a vehicle while it’s being repaired. Consumer Reports rates the S4’s reliability 34 points higher than the AMG C-Class Sedan.

From surveys of all its subscribers, Consumer Reports’ January 2024 Auto Issue reports that Audi vehicles are more reliable than Mercedes vehicles. Consumer Reports ranks Audi 10 places higher in reliability than Mercedes.

As tested in Motor Trend the Audi S4 is faster than the AMG C 43:

On the EPA test cycle the S4 gets better mileage than the AMG C-Class Sedan running its gasoline engine:

To lower fuel costs and make buying fuel easier, the Audi S4 uses regular unleaded gasoline (premium recommended for maximum performance). The AMG C-Class Sedan requires premium, which can cost on average about 84.9 cents more per gallon.

For better traction, the S4 has larger tires than the AMG C-Class Sedan (255/35R19 vs. 245/45R18).

The S4’s tires provide better handling because they have a lower 35 series profile (height to width ratio) that provides a stiffer sidewall than the AMG C-Class Sedan’s standard 45 series tires.

For better ride, handling and brake cooling the S4 has standard 19-inch wheels. Smaller 18-inch wheels are standard on the AMG C-Class Sedan.

The S4 has a standard space-saver spare tire so you can replace a flat tire and drive to have the flat repaired or replaced. A spare tire isn’t available on the AMG C-Class Sedan; it requires you to depend on its run-flat tires, which limits mileage and speed before they are repaired. If a run-flat is damaged beyond repair by a road hazard your vehicle will have to be towed. Some tire options on the AMG C-Class Sedan don’t have a run-flat feature, either.

The S4 Prestige handles at .95 G’s, while the AMG C 43 pulls only .92 G’s of cornering force in a Car and Driver skidpad test.

For better maneuverability, the S4’s turning circle is 1.2 feet tighter than the AMG C 43’s (38.1 feet vs. 39.3 feet). The S4’s turning circle is 1.6 feet tighter than the AMG C 63 S E’s (38.1 feet vs. 39.7 feet).

The Audi S4 may be more efficient, handle and accelerate better because it weighs about 300 to 850 pounds less than the Mercedes AMG C-Class Sedan.

The S4 has a larger trunk than the AMG C-Class Sedan (12 vs. 11.6 cubic feet).

In poor weather, headlights can lose their effectiveness as grime builds up on their lenses. This can reduce visibility without the driver realizing. The S4 Prestige has standard headlight washers to keep headlight output high. The AMG C-Class Sedan doesn’t offer headlight washers.

Both the S4 and the AMG C-Class Sedan have standard heated front seats. The S4 Prestige also has standard heated rear seats to keep those passengers extremely comfortable in the winter. Heated rear seats aren’t available in the AMG C-Class Sedan.

The S4 has a standard heated steering wheel to take the chill out of steering on extremely cold winter days before the car heater warms up. A heated steering wheel costs extra on the AMG C-Class Sedan.

The S4 has standard massaging front seats in order to maximize comfort and eliminate fatigue on long trips. Massaging seats aren’t available in the AMG C-Class Sedan.