The GLS’ pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Acadia doesn’t offer pre-crash pretensioners.
The Mercedes GLS has a standard driver’s side knee airbag mounted low on the dashboard. The knee airbag helps prevent the driver from sliding under the seatbelts or the main frontal airbag; this keeps the driver better positioned during a collision for maximum protection. A knee airbag also helps keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The Acadia doesn’t offer knee airbags.
The GLS offers an optional Post Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Acadia doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the GLS. But it costs extra on the Acadia.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLS has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Acadia doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the GLS and the Acadia have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, around view monitors and rear cross-path warning.
The Mercedes GLS weighs 849 to 1718 pounds more than the GMC Acadia. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

