The GLE Coupe’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Murano doesn’t offer pre-crash pretensioners.
The GLE Coupe offers optional Post-Collision Brake, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Murano doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the GLE Coupe. But it costs extra on the Murano.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The GLE Coupe has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The Murano doesn’t offer a system that can receive automated systems from other vehicles.
Both the GLE Coupe and Murano have rear cross-traffic warning, but the GLE Coupe has Active Brake Assist (automatically applies the brakes) to better prevent a collision when backing near traffic. The Murano’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the GLE Coupe and the Murano have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available lane departure warning systems.
The Mercedes GLE Coupe weighs 677 to 922 pounds more than the Nissan Murano. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

