Compare the2025 Acura MDXVS 2024 Mercedes GLS

In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the MDX are reminded to check the back seat if they opened the rear door before starting out. The GLS doesn’t offer a back seat reminder.

The Acura MDX has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The GLS doesn’t offer a front passenger side knee airbag.

Over 200 people are killed each year when backed over by motor vehicles. The MDX offers an optional Low-Speed Braking Control that uses rear sensors to monitor for objects to the rear and automatically applies the brakes to prevent a collision. The GLS doesn’t offer automatic braking for stationary objects directly to the rear.

Both the MDX and the GLS have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.

The Acura MDX has achieved the Insurance Institute for Highway Safety’s (IIHS) highest rating of “Top Safety Pick Plus” for the 2024 model year. This distinction is based on its exceptional performance in IIHS’ rigorous battery of safety tests. Specifically, it earned an “Acceptable” rating in the latest, more stringent moderate overlap front crash test, a “Good” result in the updated side impact test, and an “Acceptable” score in the revised pedestrian crash prevention test. The GLS has not yet been evaluated by the IIHS for 2024.

Acura’s powertrain warranty covers the MDX 2 years and 20,000 miles longer than Mercedes covers the GLS. Any repair needed on the engine, transmission, axles, joints or driveshafts is fully covered for 6 years or 70,000 miles. Coverage on the GLS ends after only 4 years or 50,000 miles.

A reliable vehicle saves its owner time, money and trouble. Nobody wants to be stranded or have to be without a vehicle while it’s being repaired. Consumer Reports rates the MDX’s reliability 21 points higher than the GLS.

J.D. Power and Associates’ 2024 Initial Quality Study of new car owners surveyed provide the statistics that show that Acura vehicles are better in initial quality than Mercedes vehicles. J.D. Power ranks Acura above average in initial quality. With 13 more problems per 100 vehicles, Mercedes is rated below average.

J.D. Power and Associates’ 2024 survey of the owners of three-year-old vehicles provides the long-term dependability statistics that show that Acura vehicles are more reliable than Mercedes With 2 fewer problems per 100 vehicles in the first three years of ownership, J.D. Power ranks Acura higher than Mercedes.

From surveys of all its subscribers, Consumer Reports’ January 2024 Auto Issue reports that Acura vehicles are more reliable than Mercedes vehicles. Consumer Reports ranks Acura fourth in overall reliability. Mercedes is ranked 29th.

As tested in Car and Driver the MDX Type S 3.0 turbo V6 is faster than the GLS 450 3.0 turbo 6-cylinder hybrid:

On the EPA test cycle the MDX gets better mileage than the GLS:

An engine control system that can shut down some of the engine’s cylinders helps improve the MDX’s fuel efficiency. The GLS doesn’t offer a system that can shut down part of the engine.

To lower fuel costs and make buying fuel easier, the Acura MDX uses regular unleaded gasoline (premium recommended for maximum performance). The GLS requires premium, which can cost on average about 84.9 cents more per gallon.

The MDX has a standard cap-less fueling system. The fuel filler is automatically opened when the fuel nozzle is inserted and automatically closed when it’s removed. This eliminates the need to unscrew and replace the cap and it reduces fuel evaporation, which causes pollution. The GLS doesn’t offer a cap-less fueling system.

A 10-speed automatic is standard on the Acura MDX, for better acceleration and lower engine speed on the highway. Only a nine-speed automatic is available for the GLS.

The MDX stops shorter than the GLS:

The MDX has a standard easy tire fill system. When inflating the tires, the vehicle’s integrated tire pressure sensors keep track of the pressure as the tires fill and tell the driver when the tires are inflated to the proper pressure. The GLS doesn’t offer vehicle monitored tire inflation.

Having a flat tire is dangerous, inconvenient and expensive. The self-sealing tires available on the MDX can automatically seal most punctures up to 3/16 of an inch, effectively preventing most flat tires. The GLS doesn’t offer self-sealing tires.

For better handling and stability, the track (width between the wheels) on the MDX is 1.1 inches wider in the front and .2 inches wider in the rear than the average track on the GLS.

The MDX Type S handles at .84 G’s, while the GLS 580 pulls only .83 G’s of cornering force in a Motor Trend skidpad test.

The Acura MDX may be more efficient, handle and accelerate better because it weighs about 1200 to 1450 pounds less than the Mercedes GLS.

The MDX is 6.5 inches shorter than the GLS 450, making the MDX easier to handle, maneuver and park in tight spaces.

The MDX uses computer-generated active noise cancellation to help remove annoying noise and vibration from the passenger compartment, especially at low frequencies. The GLS doesn’t offer active noise cancellation.

The MDX’s cargo area provides more volume than the GLS.

A Trailer Stability Assist is standard on the MDX, using the Vehicle Stability Assist sensors to detect trailer sway, then uses individual brakes to counteract any swaying and help keep the tow vehicle and trailer steady. A trailer sway program costs extra on the GLS.

J.D. Power and Associates surveys of service recipients show that Acura service is better than Mercedes. J.D. Power ranks Acura 9th in service department satisfaction (above the industry average). With a 12% lower rating, Mercedes is ranked 17th.

To improve rear visibility by keeping the rear window clear, the MDX has a standard rear fixed intermittent wiper with a full on position. The rear wiper standard on the GLS only has an intermittent setting, so in a hard rain visibility isn’t as good.

Consumer Reports rated the MDX’s headlight performance “Very Good,” a higher rating than the GLS’ headlights, which were rated “Good.”

The MDX is available in both front-wheel drive and four-wheel drive configurations. The GLS doesn’t offer a two-wheel drive configuration.

Insurance will cost less for the MDX owner. The Complete Car Cost Guide estimates that insurance for the MDX will cost $7225 to $13245 less than the GLS over a five-year period.

The MDX will cost the buyer less in the long run because of its superior resale value. The IntelliChoice estimates that the MDX will retain 50.63% to 53.63% of its original price after five years, while the GLS only retains 45.74% to 47.18%.

IntelliChoice estimates that five-year ownership costs (depreciation, financing, insurance, fuel, fees, repairs and maintenance) for the Acura MDX will be $41468 to $97610 less than for the Mercedes GLS.

Consumer Reports® recommends the Acura MDX, based on reliability, safety and performance. The Mercedes GLS isn't recommended.

The Acura MDX outsold the Mercedes GLS by over two to one during 2023.