The rear seatbelts optional on the EQS inflate when a collision is detected, helping to spread crash forces over a much larger area of the body and limiting head and neck movement. This can help prevent spinal and internal injuries. The LS doesn’t offer inflatable seatbelts.
The EQS’ standard pretensioning seatbelts also sense rear collisions and remove slack from the seatbelts to help protect the occupants from whiplash and other injuries. The LS doesn’t offer a whiplash protection system.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The EQS has Car-to-X Communication, a system that seamlessly communicates important warnings to the driver about impending danger, if they're available. The LS doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the EQS and the LS have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
The Mercedes EQS weighs 407 to 1168 pounds more than the Lexus LS. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.