Both the K5 and IS have child safety locks to prevent children from opening the rear doors. The K5 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The IS’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the K5 are reminded to check the back seat if they opened the rear door before starting out. The IS doesn’t offer a back seat reminder.
To help make backing out of a parking space safer, the K5 has standard Rear Cross-Traffic Collision Warning with Rear Cross-Traffic Collision-Avoidance Assist, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Rear Cross-Traffic Braking costs extra on the IS.
The K5’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The IS doesn’t offer a driver alert monitor.
Both the K5 and the IS have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available around view monitors.