Both the Panamera and E-Class Sedan have child safety locks to prevent children from opening the rear doors. The Panamera has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The E-Class Sedan’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Porsche Panamera has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The E-Class Sedan doesn’t offer a front passenger side knee airbag.
A passive infrared night vision system optional on the Panamera helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard and even aims one of the vehicle’s headlights in the direction of the person or object. The E-Class Sedan doesn’t offer a night vision system.
The Panamera’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the E-Class Sedan.
To help make backing out of a parking space safer, the Panamera has standard Rear Cross Traffic Alert and automatically engage the brakes. Mercedes charges extra for Rear Cross-Traffic Alert on the E-Class Sedan.
Both the Panamera and the E-Class Sedan have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, available all wheel drive and around view monitors.