The rear seatbelts optional on the S-Class inflate when a collision is detected, helping to spread crash forces over a much larger area of the body and limiting head and neck movement. This can help prevent spinal and internal injuries. The LS doesn’t offer inflatable seatbelts.
The S-Class’ standard pretensioning seatbelts also sense rear collisions and remove slack from the seatbelts to help protect the occupants from whiplash and other injuries. The LS doesn’t offer a whiplash protection system.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the S-Class. But it costs extra on the LS.
Earlier warning of stopped traffic, traffic signals, dangerous road conditions, weather, or accidents, can keep driver's safer and prevent crashes. The S-Class has Car-to-X Communication, a system that seemlesly communicates important warnings to the driver about impending danger, if they're available. The LS doesn’t offer a system that can receive automated systems from infrastructure or other vehicles.
Both the S-Class and the LS have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.