Both the S8 and AMG E-Class Sedan have child safety locks to prevent children from opening the rear doors. The S8 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The AMG E-Class Sedan’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Audi S8 has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The AMG E-Class Sedan doesn’t offer a front passenger side knee airbag.
The S8 has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The AMG E-Class Sedan doesn’t offer front seat center airbags.
The S8 has a standard Secondary Collision Brake Assist, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The AMG E-Class Sedan doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
A passive infrared night vision system optional on the S8 helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard and even aims one of the vehicle’s headlights in the direction of the person or object. The AMG E-Class Sedan doesn’t offer a night vision system.
The S8’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane. A lane departure warning system costs extra on the AMG E-Class Sedan.
Both the S8 and the AMG E-Class Sedan have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, around view monitors, available blind spot warning systems and rear cross-path warning.
The Audi S8 weighs 539 to 750 pounds more than the Mercedes AMG E-Class Sedan. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.