The Sequoia has standard Active Headrests, which use a specially designed headrest to protect the driver and front passenger from whiplash. During a rear-end collision, the Active Headrests system moves the headrests forward to prevent neck and spine injuries. The MDX doesn’t offer a whiplash protection system.
The Sequoia has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The MDX doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
When descending a steep, off-road slope, the Sequoia 4x4’s optional Downhill Assist Control allows you to creep down safely. The MDX doesn’t offer Downhill Assist Control.
Both the Sequoia and MDX have rear cross-traffic warning, but the Sequoia has Parking Support Brake (automatically applies the brakes) to better prevent a collision when backing near traffic. The MDX’s Rear Cross Traffic Monitor doesn’t automatically brake.
Both the Sequoia and the MDX have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available four-wheel drive.
The Toyota Sequoia weighs 832 to 1914 pounds more than the Acura MDX. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.