Both the Palisade and Sequoia have child safety locks to prevent children from opening the rear doors. The Palisade has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Sequoia’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
Full-time four-wheel drive is optional on the Palisade. Full-time four-wheel drive gives added traction for safety in all conditions, not just off-road, like the only system available on the Sequoia.
The Palisade’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Sequoia doesn’t offer a driver alert monitor.
For better protection of the passenger compartment, the Palisade uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The Sequoia uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Palisade and the Sequoia have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available around view monitors.
For its performance in IIHS driver-side and passenger-side small overlap frontal, moderate overlap frontal, updated side impact, headlight, daytime pedestrian crash prevention, and nighttime pedestrian crash prevention testing, the Insurance Institute for Highway Safety grants the Palisade its highest rating: “Top Safety Pick Plus” for 2023, a rating granted to only 29 vehicles tested by the IIHS. The Sequoia has not been tested, yet.