Both the Palisade and LX have child safety locks to prevent children from opening the rear doors. The Palisade has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The LX’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
For better protection of the passenger compartment, the Palisade uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The LX uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Palisade and the LX have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.
For its performance in IIHS driver-side and passenger-side small overlap frontal, moderate overlap frontal, updated side impact, headlight, daytime pedestrian crash prevention, and nighttime pedestrian crash prevention testing, the Insurance Institute for Highway Safety grants the Palisade its highest rating: “Top Safety Pick Plus” for 2023, a rating granted to only 29 vehicles tested by the IIHS. The LX has not been tested, yet.