Both the GV80 and CX-50 have child safety locks to prevent children from opening the rear doors. The GV80 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The CX-50’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the GV80 are reminded to check the back seat when a sensor determines the back seat is occupied. The CX-50 doesn’t offer a back seat reminder.
The GV80 has a standard front seat center airbag, which deploys between the driver and front passenger, protecting them from injuries caused by striking each other in serious side impacts. The CX-50 doesn’t offer front seat center airbags.
When descending a steep, off-road slope, the GV80’s standard Downhill Brake Control allows you to creep down safely. The CX-50 doesn’t offer Downhill Brake Control.
To help make backing out of a parking space safer, the GV80 has standard Rear Cross-Traffic Collision-Avoidance Assist with automatic braking, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Only the CX-50 Turbo Premium Plus offers Rear Cross Traffic Braking.
Both the GV80 and the CX-50 have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available around view monitors.
The Genesis GV80 weighs 599 to 1398 pounds more than the Mazda CX-50. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

