The S60’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Prius doesn’t offer pre-crash pretensioners.
Both the S60 and Prius have child safety locks to prevent children from opening the rear doors. The S60 Plus/Ultimate has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Prius’ child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Volvo S60 has a standard driver’s side knee airbag mounted low on the dashboard. The knee airbag helps prevent the driver from sliding under the seatbelts or the main frontal airbag; this keeps the driver better positioned during a collision for maximum protection. A knee airbag also helps keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The Prius doesn’t offer knee airbags.
The S60 has a standard Whiplash Protection System (WHIPS), which use a specially designed seat to protect the driver and front passenger from whiplash. During a rear-end collision, the WHIPS allows the backrest to travel backwards to cushion the occupants and the headrests move forward to prevent neck and spine injuries. At the same time the pretensioning seatbelts fire, removing slack from the belts. The Prius doesn’t offer a whiplash protection system.
To help make backing out of a parking space safer, the S60 has standard Cross Traffic Alert with Braking Intervention, systems which detect vehicles approaching from the sides and can automatically apply the brakes to prevent a collision. Parking Support Brake costs extra on the Prius.
Both the S60 and the Prius have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front and rear seatbelt pretensioners, front wheel drive, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.
The Volvo S60 weighs 437 to 1366 pounds more than the Toyota Prius. The NHTSA advises that heavier cars are much safer in collisions than their significantly lighter counterparts.
For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, its standard vehicle-to-vehicle front crash prevention system, with its optional vehicle-to-pedestrian front crash prevention system, and its standard headlight’s “Good” rating, the Insurance Institute for Highway Safety grants the S60 its highest rating: “Top Safety Pick Plus” for 2022, a rating granted to only 128 vehicles tested by the IIHS. The Prius has not been tested, yet.