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Both the Lyriq and RX have child safety locks to prevent children from opening the rear doors. The Lyriq has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The RX’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the Lyriq are reminded to check the back seat if they opened the rear door before starting out. The RX doesn’t offer a back seat reminder.
Both the Lyriq and the RX have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras and rear cross-path warning.
The Cadillac Lyriq weighs 870 to 1616 pounds more than the Lexus RX. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.