The e-tron’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Cayenne doesn’t offer pre-crash pretensioners.
Both the e-tron and Cayenne have child safety locks to prevent children from opening the rear doors. The e-tron has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Cayenne’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The e-tron’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane. A lane departure warning system costs extra on the Cayenne.
The e-tron has a standard blind spot warning system which uses sensors to alert the driver to objects in the vehicle’s blind spots where the side view mirrors don’t reveal them. A system to reveal vehicles in the Cayenne’s blind spot costs extra.
To help make backing out of a parking space safer, the e-tron has a standard rear cross-path warning system, which uses sensors in the rear bumper to alert the driver to vehicles approaching from the side, helping the driver avoid collisions. Rear cross-path warning costs extra on the Cayenne.
Both the e-tron and the Cayenne have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, rearview cameras, available night vision systems and around view monitors.
For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, its standard vehicle-to-vehicle front crash prevention system, its standard vehicle-to-pedestrian front crash prevention system, and its standard headlight’s “Good” rating, the Insurance Institute for Highway Safety grants the e-tron its highest rating: “Top Safety Pick Plus” for 2022, a rating granted to only 89 vehicles tested by the IIHS. The Cayenne has not been tested, yet.