The GLS’ pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Sequoia doesn’t offer pre-crash pretensioners.
Full-time four-wheel drive is standard on the GLS. Full-time four-wheel drive gives added traction for safety in all conditions, not just off-road, like the only system available on the Sequoia. Four-wheel drive of any type costs extra on the Sequoia.
The GLS’ driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Sequoia doesn’t offer a driver alert monitor.
For better protection of the passenger compartment, the GLS uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The Sequoia uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the GLS and the Sequoia have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, around view monitors, rear cross-path warning and available lane departure warning systems.

