Compare the2022 Audi A6VS 2021 Mercedes CLS

The A6 has a standard Secondary Collision Brake Assist, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The CLS doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.

To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the A6. But it costs extra on the CLS.

The A6’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the CLS.

Both the A6 and the CLS have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, rearview cameras, available blind spot warning systems, around view monitors and rear cross-path warning.

For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, its standard vehicle-to-vehicle front crash prevention system, its standard vehicle-to-pedestrian front crash prevention system, and its standard headlight’s “Good” rating, the Insurance Institute for Highway Safety grants the A6 its highest rating: “Top Pick Plus” for 2021, a rating granted to only 73 vehicles tested by the IIHS. The CLS has not been tested, yet.

The A6’s corrosion warranty is 7 years longer than the CLS’ (12 vs. 5 years).

From surveys of all its subscribers, Consumer Reports’ January 2021 Auto Issue reports that Audi vehicles are more reliable than Mercedes vehicles. Consumer Reports ranks Audi 6 places higher in reliability than Mercedes.

On the EPA test cycle the A6 gets better mileage than the CLS:

The A6 offers an available sequential manual gearbox (SMG). With no clutch pedal to worry about and a fully automatic mode, an SMG is much more efficient than a conventional automatic but just as easy to drive. The CLS doesn’t offer an SMG or a conventional manual transmission.

The A6 stops much shorter than the CLS:

For better traction, the A6’s optional tires are larger than the largest tires available on the CLS (255/40R20 vs. 245/40R19).

The A6 has a standard space-saver spare tire so you can replace a flat tire and drive to have the flat repaired or replaced. A spare tire isn’t available on the CLS; it requires you to depend on its run-flat tires, which limits mileage and speed before they are repaired. If a run-flat is damaged beyond repair by a road hazard your vehicle will have to be towed.

The A6 Prestige handles at .93 G’s, while the CLS 450 4MATIC pulls only .90 G’s of cornering force in a Motor Trend skidpad test.

The A6 Prestige executes Motor Trend’s “Figure Eight” maneuver quicker than the CLS 450 4MATIC (24.9 seconds @ .75 average G’s vs. 25.8 seconds @ .72 average G’s).

For better maneuverability, the A6 55 TFSI’s turning circle is 1.7 feet tighter than the CLS’ (36.4 feet vs. 38.1 feet).

Because it has more passenger and cargo room, the EPA rates the A6 a Mid-size car, while the CLS is rated a Compact.

The A6 has 6 cubic feet more passenger volume than the CLS (99 vs. 93).

The A6 has 1.1 inches more front headroom, 2.2 inches more rear headroom and 2.4 inches more rear legroom than the CLS.

The A6 has a much larger trunk than the CLS (13.7 vs. 11.9 cubic feet).

The A6’s instruments include an oil pressure gauge and a temperature gauge - which could save your engine! Often ‘idiot lights’ don’t warn you until damage has been done. The CLS does not have an oil pressure gauge.

In poor weather, headlights can lose their effectiveness as grime builds up on their lenses. This can reduce visibility without the driver realizing. The A6 Premium Plus/Prestige has standard headlight washers to keep headlight output high. The CLS doesn’t offer headlight washers.

A power rear sunshade and manual rear side window sunshades are standard in the A6 Prestige to help block heat and glare for the rear passengers. The CLS doesn’t offer rear side window sunshades.

Both the A6 and the CLS have standard heated front seats. The A6 also offers optional heated rear seats to keep those passengers extremely comfortable in the winter. Heated rear seats aren’t available in the CLS.

Consumer Reports® recommends the Audi A6, based on reliability, safety and performance.

Motor Trend performed a comparison test in its January 2019 issue and they ranked the Audi A6 Prestige higher than the Mercedes CLS 450 4MATIC.