For enhanced safety, the front and second-row seat shoulder belts of the Mercedes GLS have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Honda Pilot doesn’t offer pretensioners for its second-row seat belts.
The GLS’ pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The Pilot doesn’t offer pre-crash pretensioners.
The Mercedes GLS has a standard driver’s side knee airbag mounted low on the dashboard. The knee airbag helps prevent the driver from sliding under the seatbelts or the main frontal airbag; this keeps the driver better positioned during a collision for maximum protection. A knee airbag also helps keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The Pilot doesn’t offer knee airbags.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the GLS. But it costs extra on the Pilot.
When descending a steep, off-road slope, the GLS’ standard Downhill Speed Regulation allows you to creep down safely. The Pilot doesn’t offer Downhill Speed Regulation.
The GLS has a standard Surround View System to allow the driver to see objects all around the vehicle on a screen. The Pilot only offers a rear monitor and front and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the sides.
The GLS’ driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Pilot doesn’t offer a driver alert monitor.
Both the GLS and the Pilot have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning and available lane departure warning systems.
The Mercedes GLS weighs 1146 to 2044 pounds more than the Honda Pilot. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.

