For enhanced safety, the front and rear seat shoulder belts of the Audi S6 have pretensioners to tighten the seatbelts and eliminate dangerous slack in the event of a collision and force limiters to limit the pressure the belts will exert on the passengers. The Chrysler 300 doesn’t offer pretensioners for the rear seat belts.
The S6’s pre-crash front seatbelts will tighten automatically in the event the vehicle detects an impending crash, improving protection against injury significantly. The 300 doesn’t offer pre-crash pretensioners.
Both the S6 and 300 have child safety locks to prevent children from opening the rear doors. The S6 has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The 300’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Audi S6 has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The 300 doesn’t offer a front passenger side knee airbag.
The S6 has a standard Secondary Collision Brake Assist, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The 300 doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the S6. But it costs extra on the 300.
A passive infrared night vision system optional on the S6 Prestige helps the driver to more easily detect people, animals or other objects in front of the vehicle at night. Using an infrared camera to detect heat, the system then displays the image on a monitor in the dashboard. The 300 doesn’t offer a night vision system.
The S6’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the 300 and is only available on 300 Touring L/S.
The S6 has a standard Top and Corner View Cameras to allow the driver to see objects all around the vehicle on a screen. The 300 only offers a rear monitor and front and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the sides.
Both the S6 and the 300 have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, daytime running lights, rearview cameras, available blind spot warning systems and rear cross-path warning.
Instrumented handling tests conducted by the National Highway Traffic Safety Administration and analysis of its dimensions indicate that the S6, with its five-star roll-over rating, is 2.4% less likely to roll over than the 300, which received a four-star rating.