Compare the2022 Audi S5 SportbackVS 2021 Mercedes AMG E-Class Sedan

Both the S5 Sportback and AMG E-Class Sedan have child safety locks to prevent children from opening the rear doors. The S5 Sportback has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The AMG E-Class Sedan’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.

The Audi S5 Sportback has standard driver and front passenger side knee airbags mounted low on the dashboard. These airbags helps prevent the driver and front passenger from sliding under their seatbelts or the main frontal airbags; this keeps them better positioned during a collision for maximum protection. Knee airbags also help keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The AMG E-Class Sedan doesn’t offer a front passenger side knee airbag.

The S5 Sportback has a standard Secondary Collision Brake Assist, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The AMG E-Class Sedan doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.

When descending a steep, off-road slope, the S5 Sportback’s standard Hill Descent Control allows you to creep down safely. The AMG E-Class Sedan doesn’t offer Hill Descent Control.

The S5 Sportback’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane. A lane departure warning system costs extra on the AMG E-Class Sedan.

Both the S5 Sportback and the AMG E-Class Sedan have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, all wheel drive, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, rearview cameras, available blind spot warning systems, around view monitors and rear cross-path warning.

For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, its standard vehicle-to-vehicle front crash prevention system, its standard vehicle-to-pedestrian front crash prevention system, and its available headlight’s “Good” rating, the Insurance Institute for Highway Safety grants the S5 Sportback the rating of “Top Pick” for 2021, a rating granted to only 128 vehicles tested by the IIHS. The AMG E-Class Sedan has not been fully tested, yet.

The S5 Sportback’s corrosion warranty is 7 years longer than the AMG E-Class Sedan’s (12 vs. 5 years).

From surveys of all its subscribers, Consumer Reports’ January 2021 Auto Issue reports that Audi vehicles are more reliable than Mercedes vehicles. Consumer Reports ranks Audi 6 places higher in reliability than Mercedes.

On the EPA test cycle the S5 Sportback gets better fuel mileage than the AMG E 63 S Sedan 4.0 turbo V8 (21 city/30 hwy vs. 16 city/23 hwy).

To lower fuel costs and make buying fuel easier, the Audi S5 Sportback uses regular unleaded gasoline (premium recommended for maximum performance). The AMG E-Class Sedan requires premium, which can cost 20 to 55 cents more per gallon.

The S5 Sportback stops shorter than the AMG E-Class Sedan:

For better traction, the S5 Sportback has larger standard tires than the AMG E-Class Sedan (255/35R19 vs. 245/40R19).

The S5 Sportback’s standard tires provide better handling because they have a lower 35 series profile (height to width ratio) that provides a stiffer sidewall than the AMG E 53’s standard 40 series front tires. The S5 Sportback’s optional tires have a lower 30 series profile than the AMG E 63 S’ 35 series front tires.

The S5 Sportback has a standard space-saver spare tire so you can replace a flat tire and drive to have the flat repaired or replaced. A spare tire isn’t available on the AMG E-Class Sedan; it requires you to depend on its run-flat tires, which limits mileage and speed before they are repaired. If a run-flat is damaged beyond repair by a road hazard your vehicle will have to be towed. Some tire options on the AMG E-Class Sedan don’t have a run-flat feature, either.

For better maneuverability, the S5 Sportback’s turning circle is 2.6 feet tighter than the AMG E-Class Sedan’s (38.4 feet vs. 41 feet).

The Audi S5 Sportback may be more efficient, handle and accelerate better because it weighs about 550 pounds less than the Mercedes AMG E-Class Sedan.

The S5 Sportback is 7.9 inches shorter than the AMG E 53, making the S5 Sportback easier to handle, maneuver and park in tight spaces.

The design of the Audi S5 Sportback amounts to more than styling. The S5 Sportback has an aerodynamic coefficient of drag of .3 Cd. That is lower than the AMG E-Class Sedan (.32) and many sports cars. A more efficient exterior helps keep the interior quieter and helps the S5 Sportback get better fuel mileage.

As tested by Car and Driver, the interior of the S5 Sportback Prestige is quieter than the AMG E 63 S:

In poor weather, headlights can lose their effectiveness as grime builds up on their lenses. This can reduce visibility without the driver realizing. The S5 Sportback has standard headlight washers to keep headlight output high. The AMG E-Class Sedan doesn’t offer headlight washers.

To shield the driver and front passenger’s vision over a larger portion of the windshield and side windows, the S5 Sportback has standard extendable sun visors. The AMG E-Class Sedan doesn’t offer extendable visors.