Both the Santa Fe and Grand Cherokee have child safety locks to prevent children from opening the rear doors. The Santa Fe has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Grand Cherokee’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the Santa Fe are reminded to check the back seat if they opened the rear door before starting out. The Grand Cherokee doesn’t offer a back seat reminder.
Over 200 people are killed each year when backed over by motor vehicles. The Santa Fe Limited/Calligraphy has standard Parking Collision Avoidance Assist that uses rear sensors to monitor and automatically apply the brakes to prevent a rear collision. The Grand Cherokee doesn’t offer backup collision prevention brakes.
The Santa Fe’s standard lane departure warning system alerts a temporarily inattentive driver when the vehicle begins to leave its lane and gently nudges the vehicle back towards its lane. A lane departure warning system costs extra on the Grand Cherokee.
The Santa Fe Limited/Calligraphy has a standard Surround View Monitor to allow the driver to see objects all around the vehicle on a screen. The Grand Cherokee only offers a rear monitor and front and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the sides.
The Santa Fe’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Grand Cherokee doesn’t offer a driver alert monitor.
Both the Santa Fe and the Grand Cherokee have standard driver and passenger frontal airbags, front side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning and available all wheel drive.