Both the Telluride and Sequoia have child safety locks to prevent children from opening the rear doors. The Telluride has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Sequoia’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the Telluride are reminded to check the back seat when a sensor determines the back seat is occupied. The Sequoia doesn’t offer a back seat reminder.
Full-time four-wheel drive is optional on the Telluride. Full-time four-wheel drive gives added traction for safety in all conditions, not just off-road, like the only system available on the Sequoia.
The Telluride SX has a standard Surround View Monitor to allow the driver to see objects all around the vehicle on a screen. The Sequoia only offers a rear monitor and front and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the sides.
For better protection of the passenger compartment, the Telluride uses safety cell construction with a three-dimensional high-strength frame that surrounds the passenger compartment. It provides extra impact protection and a sturdy mounting location for door hardware and side impact beams. The Sequoia uses a body-on-frame design, which has no frame members above the floor of the vehicle.
Both the Telluride and the Sequoia have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
Instrumented handling tests conducted by the National Highway Traffic Safety Administration and analysis of its dimensions indicate that the Telluride is 3% to 4.2% less likely to roll over than the Sequoia.
For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, its standard vehicle-to-vehicle front crash prevention system, its standard vehicle-to-pedestrian front crash prevention system, and its available headlight’s “Acceptable” rating, the Insurance Institute for Highway Safety grants the Telluride the rating of “Top Pick” for 2021, a rating granted to only 120 vehicles tested by the IIHS. The Sequoia has not been tested, yet.